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Feedback Please let us know what you think of our products and services. Give Feedback. Get Information. JSmol Viewer. Open Access Article. This article belongs to the Special Issue Clostridium Neurotoxins. Each chromosomal region was ordered based on the maximum likelihood phylogenetic tree of P Values indicated on the tree branches are bootstrapping values iterations.
The color-coded blocks correspond to different amino acid motifs detected within the analyzed protein sequences and serve to visualize the similarities between the proteins. The botulinum neurotoxin BoNT has been extensively researched over the years in regard to its structure, mode of action, and applications.
Nevertheless, the biological roles of four proteins encoded from a of BoNT gene clusters, i. Here, we investigated the diversity of orfX-p47 gene clusters using in silico analytical tools. We show that the orfX-p47 cluster was not only present in the genomes of BoNT-producing bacteria but also in a substantially wider range of bacterial species across the bacterial phylogenetic tree.
Our work also led to the identification of a putative novel BoNT-like toxin gene cluster in a Bacillus isolate. View Full-Text. Keywords: botulinum neurotoxin; neurotoxin gene cluster; orfX ; p47 ; neurotoxin associated proteins botulinum neurotoxin ; neurotoxin gene cluster ; orfX ; p47 ; neurotoxin associated proteins.
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